2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W714048
    Laduviglusib-d4 98%
    Laduviglusib-d4 (CHIR-99021-d4) is the deuterium labeled Laduviglusib (HY-10182). Laduviglusib (CHIR-99021) is a potent, selective and orally active GSK-3α/β inhibitor with IC50s of 10 nM and 6.7 nM. Laduviglusib shows >500-fold selectivity for GSK-3 over CDC2, ERK2 and other protein kinases. Laduviglusib is also a potent Wnt/β-catenin signaling pathway activator. Laduviglusib enhances mouse and human embryonic stem cells self-renewal. Laduviglusib induces autophagy.
    Laduviglusib-d4
  • HY-W714183
    Dinitramine 29091-05-2 98%
    Dinitramine is a herbicide. Dinitramine activates the Erk/P38/JNK/MAPK pathway and inactivates the PI3k/Akt pathway in testicular cells. Dinitramine induces endoplasmic reticulum stress, dysregulation of calcium homeostasis in the cytoplasm and mitochondria, apoptosis, and downregulated expression of cell cycle genes in testicular cells. Dinitramine reduces the viability and proliferation capacity of testicular cells, and inhibits cell division by suppressing the synthesis of tubulin. Dinitramine induces abnormal heart development, inhibited angiogenesis, inflammatory responses, apoptosis, and impaired embryonic growth in zebrafish embryos.
    Dinitramine
  • HY-W714217
    Silafluofen 105024-66-6 98%
    Silafluofen is a hormone sensitive lipase (HSL) inhibitor. Silafluofen is an insecticide.
    Silafluofen
  • HY-W714890
    DL-Tryptophan-d5 1027104-20-6 98%
    DL-Tryptophan-d5 ((±)-Tryptophan-d5) is the deuterium labeled DL-Tryptophan (HY-W012480). DL-Tryptophan is an endogenous metabolite.
    DL-Tryptophan-d5
  • HY-W716688
    Isosorbide-d8 98%
    Isosorbide-d8 is the deuterium labeled Isosorbide (HY-B1469). Isosorbide (D-Isosorbide), an orally active vasodilating agent that can be used for the research of heart failure and angina (chest pain). Isosorbide is also an oral hyperosmotic diuretic.
    Isosorbide-d8
  • HY-W717654
    1-Deoxy-D-xylulose 5-phosphate 190079-18-6 98%
    1-Deoxy-D-xylulose 5-phosphate (DXP) is a biosynthetic precursor to isoprenoids, thiamin (vitamin B1), and pyridoxol (vitamin B6). 1-Deoxy-D-xylulose 5-phosphate can be utilized in metabolic research.
    1-Deoxy-D-xylulose 5-phosphate
  • HY-W718037
    3-Chloro-2-(octanoyloxy)propyl decanoate-d5 2692623-31-5 98%
    3-Chloro-2-(octanoyloxy)propyl decanoate-d5 is a glycerolipid.
    3-Chloro-2-(octanoyloxy)propyl decanoate-d5
  • HY-W718042
    1-Lauroyl-2-decanoyl-3-chloropropanediol-d5 2692623-34-8 98%
    1-Lauroyl-2-decanoyl-3-chloropropanediol-d5 is a deuterated 3-monochloropropanediol (3-MCPD) glycidyl ester.
    1-Lauroyl-2-decanoyl-3-chloropropanediol-d5
  • HY-W718849
    4,8-Dimethylnonanoyl-CoA 204120-61-6 98%
    4,8-Dimethylnonanoyl-CoA (4,8-Dimethylnonanoyl-Coenzyme A) is a coenzyme A derivative.
    4,8-Dimethylnonanoyl-CoA
  • HY-W719281
    (R)-Pantetheine-d4 98%
    (R)-Pantetheine-d4 (Pantetheine-d4) is the deuterium labeled (R)-Pantetheine (HY-126050). (R)-Pantetheine is the biosynthetic precursor to CoA. (R)-Pantetheine and its corresponding disulfide pantethine, play a key role in metabolism as a building block of coenzyme A (CoA). (R)-Pantetheine has high toxicity.
    (R)-Pantetheine-d4
  • HY-W719731
    3-Oxohexadecanoyl-CoA 34619-89-1 98%
    3-Oxohexadecanoyl-CoA (3-Oxohexadecanoyl-coenzyme A) is a derivative of coenzyme A.
    3-Oxohexadecanoyl-CoA
  • HY-W720448
    VR23-d8 2733154-83-9 98%
    VR23-d8 is the deuterium labeled VR23 (HY-18741). VR23 is a small molecule that potently inhibits the activities of trypsin-like proteasomes (IC50=1 nM), chymotrypsin-like proteasomes (IC50=50-100 nM), and caspase-like proteasomes (IC50=3 μM).
    VR23-d8
  • HY-W720879
    Fesoterodine-d3 1126611-84-4 98%
    Fesoterodine-d3 is the deuterium labeled Fesoterodine (HY-70053). Fesoterodine is an orally active, nonsubtype selective, competitive muscarinic receptor (mAChR) antagonist with pKi values of 8.0, 7.7, 7.4, 7.3, 7.5 for M1, M2, M3, M4, M5 receptors, respectively. Fesoterodine is used for the overactive bladder (OAB).
    Fesoterodine-d3
  • HY-W720961
    Dimethachlor-d6 2733388-00-4 98%
    Dimethachlor-d6 is the deuterium labeled Dimethachlor (HY-121423). Dimethachlor, a synthetic herbicide, inhibits the undesirable growth of weeds via the suppression of very long-chain fatty acid synthesis. Dimethachlor disrupts normal developmental processes via the induction of apoptosis and ROS production.
    Dimethachlor-d6
  • HY-W722556
    5α-Androstan-3α-ol 7657-50-3 98%
    5α-Androstan-3α-ol is a γ-aminobutyric acid (GABA) receptor agonist. 5α-Androstan-3α-ol can inhibit the transcriptional activity of the orphan nuclear receptor CAR (constitutive androstane receptor). 5α-Androstan-3α-ol negatively regulates the activity of CAR by binding to CAR and promoting its dissociation from coactivator proteins. 5α-Androstan-3α-ol can be used to study nuclear receptor-mediated hormone metabolism and drug detoxification mechanisms.
    5α-Androstan-3α-ol
  • HY-W723322
    Ethyl tosylcarbamate-d7 98%
    Ethyl tosylcarbamate-d7 is the deuterium labeled Ethyl tosylcarbamate (HY-135337). Ethyl tosylcarbamate is an intermediate in the synthesis of Gliclazide (G409877). Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM.
    Ethyl tosylcarbamate-d7
  • HY-W724319
    Citric acid-d4 trisodium 2704-20-3 98%
    Citric acid-d4 trisodium (Sodium citrate-d4) is the deuterium labeled Citric acid trisodium (HY-B2201). Citric acid trisodium (Sodium citrate) is a natural preservative and food tartness enhancer. Citric acid trisodium induces apoptosis and cell cycle arrest at G2/M phase and S phase in HaCaT cells. Citric acid trisodium cause oxidative damage of the liver by means of the decrease of antioxidative enzyme activities. Citric acid trisodium is also an acidulant, emulsifier, sequestrant and buffering agent widely used across many industries.
    Citric acid-d4 trisodium
  • HY-W724345
    Fomepizole-d2 98%
    Fomepizole-d2 (4-Methylpyrazole-d2) is the deuterium labeled Fomepizole (HY-B0876). Fomepizole (4-Methylpyrazole) is a potent cytochrome P450 (CYP2E1) inhibitor. Fomepizole is a competitive inhibitor of the enzyme alcohol dehydrogenase. Fomepizole blocks further conversion of methanol and ethylene glycol to toxic metabolites. Fomepizole has the potential for an antidote for ethylene glycol or methanol poisoning.
    Fomepizole-d2
  • HY-W724350
    2,3,5-Trimethylpyrazine-d10 98%
    2,3,5-Trimethylpyrazine-d10 is the deuterium labeled 2,3,5-Trimethylpyrazine (HY-W010476). 2,3,5-Trimethylpyrazine is an endogenous metabolite.
    2,3,5-Trimethylpyrazine-d10
  • HY-W725130
    Allodeoxycholic acid 1912-55-6 98%
    Allodeoxycholic acid is a nucleoside metabolite.
    Allodeoxycholic acid
Cat. No. Product Name / Synonyms Application Reactivity